EXAMPLE. A client was interested in patterns observed in the ORF distribution of a particular micro-organism and would like to know the biological relevance of the observations. MMGC analysed the patterns and correlated to the biological properties of the organism. This opened a new field of computer-based research.
EXAMPLE. A client had performed subtractive hybridization with two strains of one bacterial species. The resulting clones had been partially sequenced. Most gene fragmens had no or only weak hits in BLAST. A thorough analysis was performed by MMGC to identify the top 10 candidates to focus the wet-lab research.This resulted in a fast and resource-efficient breakthrough.
EXAMPLE. A client wanted to identify particular gene combinations in a bacterial genome responsible for a particular, complex phenotype. Total bacterial genome comparison was performed with PSI-BLAST and rthe outcome was elated to known phenotypes to deduce this complex information to workable hypotheses.
EXAMPLE. A client was working on a particular antibiotic resistant gene and ordered a literature review. This was extended to a review of available sequences. Phylogenetic anaysis, performed at MMGC, resulted in a new mechanism of spread of this resistance gene, which opened a new field of laboratory research.