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Selected Publications

  • Neurobiology of sleep and microbiomics in aging. Larson-Prior L, Azhar G, Davila DG, Jun, S-R, Kemp AS, Nookaew I, Wei JY, Wassenaar TM. (2017) OBM Neurobiol.1:(2) PDF - open source
  • Survival of probiotic E. coli and Ent. faecalis in the human host after oral intake: results from in vitro and in vivo studies. Wassenaar TM, Marzorati M, Beimfohr C, Siegl A, Zimmermann K. (2017). Adv Biotechn Microbiol. 2(4): 555592.. PDF - open source
  • Insights from 100 years of studying probiotic E. coli. Wassenaar. (2016) EUJMI. 6:147-161. PDF - open source
  • The qacC gene has recently spread between rolling circle plasmids of Staphylococcus, indicative of a novel gene transfer mechanism. Wassenaar TM, Ussery DW, Ingmer H. (2016) Frontiers Microbiol. 7:1528. PDF - open source
  • Integrated MRSA-Management (IMM) with prolonged decolonization treatment after hospital discharge is effective: a single centre, non-randomised open-label trial. Jahn B, Wassenaar TM, Stroh A. (2016) Antimicr Res Infect Contr. 5:25. . PDF - open source
  • Diversity of Pseudomonas Genomes, Including Populus-Associated Isolates, as Revealed by Comparative Genome Analysis. Jun S-R, Wassenaar TM, Nookaew I, Hauser L, Wanchai V, Land M, Timm C, Lu T-Y S, Schadt CW, Doktycz MJ, Pelletier DA, Ussery DW. (2015)  Appl Environm Microbiol 82:375-382. PDF - open source
  • Ebolavirus comparative genomics. Jun S-R, Leuze MR, Nookaew I, Uberbacher EC, Land M, Zhang Q, Wanchai V, Chjai J, Nielsen M, Trolle T, Lund O, Buzard G, Pedersen T, Wassenaar TM, Ussery DW. (2015)  FEMS Microbiol. Rev. FEMS Microbiol Rev. 39:764-778. PDF - open source
  • The prediction of virulence based on presence of virulence genes in E. coli may not always be accurate. Wassenaar TM, Gunzer F (2015) Gut Pathogens 7:15. PDF - open source
  • Insights from twenty years of bacterial genome sequencing. Land M, Hauser L, Jun S-R, Nookaew I, Leuze MR, Ahn T-H, Karpinets T, Lund  O, Kora G, Wassenaar T, Poudel S, Ussery DW. (2015)  Funct Integr Genom. 15:141-161. PDF - open source
  • Review and phylogenetic analysis of qac genes reducing susceptibility to quaternary ammonium compounds in Staphylococcus species. Wassenaar TM, Ussery DW, Nielsen LN, Ingmer H. (2015) EUJMI, 5:44-61. PDF - open source
  • Virulence genes in a probiotic E. coli product with a recorded long history of safe use. Wassenaar TM, Zschüttig A, Beimfohr B, Geske T, Auerbach C, Cook H, Zimmermann K, Gunzer F. (2015) EUJMI, 5:81-93. PDF - open source
  • Method comparison for enhanced recovery, isolation and qualitative detection of Campylobacter jejuni and C. coli from waste water effluent water samples. Ugarte-Ruiz M, Florez-Cuadrado D, Wassenaar TM, Porrero MC, Domínguez L. (2015)  Int J Res Public Health 12:2749-64. PDF - open source
  • Complete sequence of probiotic Symbioflor 2 E. coli strain G3/10 and draft sequences of Symbioflor 2 E. coli strains G1/2, G4/9, G5, G6/7 and G8. Zschüttig A, Auerbach C, Meltke S, Eichhorn C, Brandt M, Blom J, Goesmann A, Jarek M, Scharfe M, Zimmermann K, Wassenaar T, Gunzer F. (2015)  Genome Announc. 3: e01330-14. PDF - open source
  • Is a fetus developing in a sterile environment? Wassenaar TM, Pahigrani P. (2014)  L Appl Microbiol. 59: 572-579. PDF - open source
  • Voluntarily exposure to a single, high dose of Symbioflor2 results in prolonged colonization of probiotic E. coli. Wassenaar TM, Beimfohr C, Geske T, Zimmermann K (2014)  Beneficial Microbes 5: 367-375. PDF - open source
  • Veillonella, Firmicutes disguiesed as Gram negatives. Vesth T, Ozen A, Andersen S, Sommer Kaas R, Lukjancenko O, Bohlin J, Nookaew I, Wassenaar T, Ussery DW. (2013) SIGS 9:431-448. PDF - open source
  • The effect of different isolation protocols on detection and molecular characterization of Campylobacter from poultry. Ugarte-Ruiz M, Wassenaar TM, Gómez-Barrero S, Porrero MC, Domínguez L. (2013)  L Appl Microbiol. 427-435. PDF - open source
  • Detection of Methicillin Resistant Staphylococcus aureus in Iberian pigs. Porrero MC, Wassenaar TM, Gómez-Barrero S, García M, Bárcena C, Álvarez J, Sáez-Llorente JL, Fernández-Garayzábal JF, Moreno MA, Domínguez L. (2012) Lett Appl Microbiol. 54:280-285. PDF - open source
  • Evaluation of four protocols for the detection and isolation of thermophilic Campylobacter from different matrices. Ugarte-Ruiz M, Gómez-Barrero S, Porrero MC, Alvarez J, García M, Comerón MC, Wassenaar TM, Domínguez L. (2012) J Appl Microbiol. 113:200-208. PDF - open source
  • Analysis of evolutionary patterns of genes in Campylobacter jejuni and C. coli. Snipen L, Wassenaar T, Altermann E, Olson J, Kathariou S, Lagesen K, Takamiya M, Knochel S, Ussery DW, Meinersmann RJ. (2012) Microb. Inform. Expt. 2:8. PDF - open source
  • Comparative genomics of Bifidobacterium, Lactobacillus and related probiotic genera. Lukjancenko O, Ussery DW, Wassenaar TM. (2011) Microb. Ecol. 63:651-673. PDF - open source
  • Following an imaginary Campylobacter population from farm to fork and beyond: a bacterial perspective. Wassenaar TM. (2011) J Appl Microbiol 53:253-263. PDF - open source
  • The thousandth genome - a cautionary tale. Lagesen K, Ussery DW,  Wassenaar TM. (2010) Microbiology 156:603-608. PDF - open source
  • Comparison of 61 sequenced Escherichia coli genomes. Lukjancenko O, Wassenaar TM,  Ussery DW (2010) Microb Ecol. 60:708-720. PDF - open source
  • Genomic characterization of Campylobacter jejuni strain M1. Friis C, Wassenaar TM, Javed MA, Snipen L, Lagesen K, Newell DG, Manning G,  Ussery DW. (2010) PLoS One 5(8): e12253. PDF - open source
  • Comparison of Campylobacter fla-SVR genotypes isolated from humans and poultry in three European regions. Wassenaar TM, Fernández-Astorga A, Alonso R, Marteinsson VT, Magnússon SH, Kristoffersen AB, Hofshagen M. (2009) Lett Appl Microbiol. 49:388-395 PDF - open source
  • On the origins of a Vibrio species. Vesth T, Wassenaar TM, Hallin P, Snipen L, Lagesen K, Ussery DW (2009) Microb Ecol. 59:1-13. PDF - open source
  • The genus Burkholderia: analysis of 56 genomic sequences. Ussery DW. Kiil K, Lagesen K, Sicheritz-Pontèn K, Bohlin J, Wassenaar TM. (2009) Genome Dyn. 6:140-157. PDF - first page
  • Genome comparison of bacterial pathogens. Wassenaar TM, Bohlin J, Binnewies TT, Ussery DW. (2009) Genome Dyn. 6:1-20. PDF - first page
  • Antimicrobal resistance in zoonotic bacteria: lessons learned from host-specific pathogens. Wassenaar TM, Silley P. (2008) Animal Health Res. Rev. 92:177-186. PDF - first page
  • Safety aspects of bacterial food supplements.  Wassenaar TM, Klein G. (2008) J. Food Prot. 71:1734-1741. PDF - first page
  • Putative identification of an amphipatic, alpha-helical sequence inhemolysin of E. coli (HlyA) involved in transmembrane pore formation. Valeva A, Siegel I, Wylenzek M, Wassenaar TM, Weis S, Heinz N, Schmitt R, Fischer C, Reinarzt R, Bhakdi S, Walev I. (2008) Biol Chem. 389: 1201-1207. PDF - first page
  • The identification of hyperinvasive Campylobacter jejuni strains in poultry and human clinical isolates. Fearnley C, Manning G, Bagnall M, Javed MA, Wassenaar TM, Newell DG. (2008) J Med Microbiol. 57:570-580. PDF - first page
  • Genetic instability is associated with changes in the colonization potential of Campylobacter jejuni in the avian intestine. Ridley AM, Toszeghy MJ, Cawthraw, SA, Wassenaar TM, Newell DG. (2008) J Appl Microbiol. 105:95-104. PDF - first page
  • Development of a strain-specific molecular method for quantitating individual Campylobacter strains in mixed poopulations. Elvers KT, Helps CR, Wassenaar TM, Allen VM, Newell DG. (2008) Appl Environm Microbiol. 74:2321-2331. PDF - first page
  • The importance of virulence prediction and gene networks in microbial risk assessment. Wassenaar TM, Gamieldien J, Shatkin J, Luber P, Moyer N, Carpenter T., Ussery DW. (2007) Human  Ecol Risk Assessm. 2: 254-268.
  • Characterization of probiotic Escherichia coli isolates with a pan-genome microarray. Willenbrock H, Hallin PF, Wassenaar TM,  Ussery DU. (2007) Genome Biol. 8:R267. PDF - open source
  • Pro-inflammatory feedback activation cycle evoked by attack of Vibrio cholerae cytolysin on human neutrophil granulocytes. Valeva A, Walev I, Weis S, Boukhallouk F, Wassenaar TM,  Bhakdi S. (2007) Med Microbiol.Immunol. 197:285-293.
  • Re-analysis of the risks attributed to ciprofloxacin-resistant Campylobacter jejuni infections. Wassenaar TM, Kist M,  de Jong A. (2007) Int J Antimicrob Agents 30:195-201. PDF - first page
  • Genotyping of Human and Porcine Yersinia enterocolitica, Yersinia intermedia and Yersinia bercovieri Strains from Switzerland by Amplified Fragment Length analysis Polymorphism (AFLP). Boghenbor KK, On SLW, Kokotovic B, Frey J, Baumgartner A, Wassenaar TM, Wittwer M, Bissig-Choisat B. (2006) Appl Environm Microbiol. 72:4061-4066. PDF - first page
  • Ten years of bacterial genomes sequencing: comparative genomics based discoveries. Binnewies TT, Motro Y, Hallin PF, Lund O, Dunn D, Hampson D, Bellgard M, Wassenaar TM,  Ussery DW. (2006) Funct Integr Genomics 6:165-185. PDF - first page
  • Phenon cluster analysis as a method to investigate epidemiological relatedness between sources of Campylobacter jejuni. Wieland B, Wittwer M, Regula G, Wassenaar TM, Burnens AP, Keller J,  Stärk KDC. (2006) J Appl Microbiol. 100:316-324. PDF - first page
  • Evidence of host-virus co-evolution in tetranucleotide usage patterns of bacteriophages and eukaryotic viruses. Pride D, Wassenaar TM, Ghose C,  Blaser MJ. (2006) BMC Genomics 7:8. PDF - first page
  • Detection of Mycobacterium avium subspecies paratuberculosis in Swiss dairy and mother cattle by real-time PCR, culture and serology. Bögli-Stuber K, Kohler C, Seitert G, Glanemann B, Antognoli M., Salman MD, Wittenbrink MM, Wittwer M, Wassenaar T, Jemmi T,  Bissig-Choisat B. (2005) J Appl Microbiol. 99:587-597.
  • Role of dprA in transformation in Campylobacter jejuni. Takata T, Ando T, Israel D, Wassenaar TM,Blaser MJ. (2005) FEMS Microbiol Lett. 252:161-168. PDF - first page
  • Genome update: sigma factors in 240 bacterial genomes. Kill K, Binnewies TT, Sicheritz-Ponten T, Willenbrock H, Hallin PF, Wassenaar TM,  Ussery DW. (2005) Microbiology. 151:3147-3150. PDF - first page
  • Phage therapy reduces Campylobacter jejuni colonization in broilers. Wagenaar JA, Van Bergen MAP, Mueller MA, Wassenaar TM, Carlton RM. (2005) Vet Microbiol. 109:275-283. PDF - first page
  • Campylobacter spp. in dogs and cats in Switzerland: risk factor analyses and AFLP characterization. Wieland B, Regula G, Danuser J, Wittwer M, Burnens AP, Wassenaar TM, Stärk KDC. (2005) J Vet Med. Series B 52:183-189.
  • Binding of E. coli hemolysin and activation of the target cells is not receptor-dependent. Valeva A, Walev I, Kemmer H, Weis S, Siegel I, Wassenaar TM, Chavakis T, Bhakdi S. (2005) J Biol Chem. 280:36657-36663. PDF - first page
  • Genome update: protein secretion systems in 225 bacterial genomes. Binnewies TT, Bendsen JD, Hallin PF, Nielsen N, Wassenaar TM, Pedersen MB, Klemm P, Ussery DW. (2005) Microbiology. 151:1013-1016. PDF - first page
  • Identification of the membrane penetrating domain of Vibrio cholerae cytolysin as a beta-barrel structure. Valeva A, Walev I, Boukhallouk F, Wassenaar TM, Heinz N,, Hedderich J, Lautwein S, Möcking M, Weis S, Zitzer A,Bhakdi S. (2005) Mol Microbiol. 57:124-131. PDF - first page
  • Use of antimicrobial agents in veterinary medicine and implications to human health. Wassenaar TM. (2005) Critical Reviews in Microbiology 31:155-169. PDF - first page
  • Cytolethal Distending Toxin (CDT) negative Campylobacter jejuni strains and anti-CDT antibodies induced during human infection. AbuOun M, Manning G, Cawthraw SA, Ridley A, Ahmed IH, Wassenaar TM, Newell DG. (2005) Infect Immun. 73:3053-3062. PDF - first page
  • Genetic diversity and antibiotic resistance patterns in a Campylobacter population isolated from poultry farms in Switzerland. Wittwer M, Keller J, Wassenaar TM, Stephan R, Howald D, Regula G, Bissig-Choisat B. (2005) Appl Environm.Microbiol. 71:2840-2847. PDF - first page
  • Detection of Mycobacterium avium subspecies paratuberculosis in Swiss dairy and mother cattle by real-time PCR, culture and serology. Bogli-Stuber K, Seitert G, Kohler C, Glanemann B, Antognoli MC, Salman MD, Wittenbrink MM Wittwer M, Wassenaar T, Bissig-Choisat B. (2005) J Appl Microbiol. 99:587-597.
  • Genome Update: tRNA's in sequenced microbial genomes. Ussery DW, Hallin PF, Lagesen K, Wassenaar TM. (2004) Microbiology. 150:1113-1115. PDF - first page
  • A cellular protease activates Vibrio cholerae pro-cytolysin. Valeva A, Walev I, Weis S, Boukhallouk F, Wassenaar TM, Bhakdi S, Zitzer A. (2004) J Biol.Chem. 279:25143-25148. PDF - first page
  • Risk Assessment prediction from genome sequences, promises and dreams. Wassenaar TM. (2004) J Food Protection 67:2053-2057. PDF - first page
  • The TGA stop codon and the phylogeny of the selenocysteine pathway. Wassenaar TM and Meinersmann RJ. (2003) Genome Letters. 2:127-138.
  • Patterns in the intergenic regions of Campylobacter jejuni. Meinersmann RJ, Wassenaar TM. (2003) Genome Letters 2:28-33.
  • Molecular typing of pathogens. Wassenaar,TM. (2003) Berl Muench Tieraertzl Wbl. 116:447-453. PDF - first page
  • Structure and genotypic plasticity of the Campylobacter fetus sap locus. Tu ZC, Wassenaar TM, Thompson SA, Blaser MJ (2003) Mol Microbiol. 48:685-698. PDF - first page
  • PCR detection of virulence genes in Yersinia enterocolitica and Yersinia pseudotuberculosis and investigation of virulence gene distribution. Thoerner P, Bin Kingombe CI, Bissig-Choisat B, Bögli-Stuber K, Wassenaar TM, Frey J, Jemmi T (2003) Appl Environm Microbiol. 69:1810-1816. PDF - first page
  • Evolutionary implications of microbial genome tetranucleotide frequency biases. Pride DT, Meinersmann RJ, Wassenaar TM , Blaser MJ  (2003) Genome Research 13:145-158. PDF - first page
  • Evolutionary history of hrgA, which replaces the restriction gene hpyIIIR in the hpyIII locus of H. pylori. Ando T, Aras RA, Kusugami K,  Blaser MJ, Wassenaar TM (2003) J Bacteriol. 185:295-301. PDF - first page
  • Homonucleotide stretches in chromosomal DNA of Campylobacter jejuni display high frequency polymorphism as detected by direct PCR analysis. Wassenaar TM, Wagenaar JA, Rigter A, Fearnley C, Newell DG, Duim B (2002) FEMS Microbiol Lett. 212:77-85. PDF - first page
  • Development and application of a new Scheme for typing Campylobacter jejuni and Campylobacter coli by PCR-based Restriction Fragment Length Polymorphism Analysis. Feng S, Yuen YC, Wassenaar TM, Woods WH, Coloe PJ, Fry BN (2002) J Clin Microbiol. 40:1791-1797. PDF - first page
  • A Helicobacter pylori restriction endonuclease replacing gene, hrgA, associated with gastric cancer in Asian strains. Ando T, Wassenaar TM, Peek RM, Aras RA, Tschumi AI, van Doorn L-J, Kusugami K,  Blaser MJ (2002) Cancer Research 62:2385-2389. PDF - first page
  • Contagion on the internet. Wassenaar TM, Blaser MJ (2002) Emerg Infect Dis. 8: 335-336. PDF - first page
  • Identification of genetic differences between two Campylobacter jejuni strains with different colonisation potentials. Ahmed I, Manning G, Wassenaar T, Crawthraw S, Newell D (2002) Microbiology 148:1203-1212. PDF - first page
  • Bacterial virulence, where to draw the line? FEMS Microbiol. Wassenaar TM, Gaastra W. (2001) Letters 201:1-7. PDF - first page
  • Evidence for a genetically stable clone of Campylobacter jejuni. Manning G, Duim B, Wassenaar TM, Wagenaar JA, Ridley A,Newell DG.  (2001) Appl Environm Microbiol. 67:1185-1189.
  • Genetic characterisation of Campylobacter jejuni O:41 in relation to Guillain Barré Syndrome. Wassenaar TM, Lastovica A, Duim B, Wagenaar J, Fry B  (2000) J Clin Microbiol. 38: 874-876. PDF - first page
  • Genotyping of Campylobacter spp. Wassenaar TM, Newell DG. (2000) Appl Environm Microbiol. 66: 1-9. PDF - first page
  • Pathophysiology of Campylobacter infections of humans. Wassenaar TM, Blaser MJ (1999) Microb Infect. 1: 1023-1033. PDF - first page
  • High-resolution genotyping of Campylobacter strains isolated from poultry and humans with AFLP fingerprinting. Duim B, Wassenaar TM, Rigter A, Wagenaar J (1999) Appl Environm Microbiol. 65: 369-2375. PDF - first page
  • Evidence of genomic instability in Campylobacter jejuni isolated from poultry meat. Wassenaar TM, Geilhausen B, Newell DG  (1998) Appl Environm Microbiol. 64: 1816-1821. PDF - first page
  • Differential up uptake and killing potential of Campylobacter jejuni by human peripheral monocytes/macrophages. Wassenaar TM, Engelskirchen M, Park S, Lastovica A (1997) Med Microbiol Immunol. 186: 139-144.
  • Mode of primary binding to target membranes and pore formation induced by Vibrio cholerae cytolysin (hemolysin). Zitzer A, Palmer M, Weller U, Wassenaar T, Biermann C, Tranum-jensen J, Bhakdi S (1997) Eur J Biochem. 247: 209-216.
  • Potent membrane-permeabilizing and cytocidal action of Vibrio cholerae cytolysin (hemolysin) on human intestinal cells Infect. Zitzer A, Wassenaar TM, Walev I, Bhakdi S (1997) Inf. Immun. 65: 1293-1298. PDF - first page
  • Toxin production by Campylobacter spp. Wassenaar TM. (1997) Rev Clin Microbiol. 10: 466-476. PDF - first page
  • Increased colonization potential of Campylobacter jejuni strain 81116 after passage through chickens and its implication on the rate of transmission within flocks. Cawthraw SA, Wassenaar TM, Ayling R, Newell DG (1996) Epidemiol Infect. 117: 213-215.
  • Variation of the flagellin gene locus of Campylobacter jejuni by recombination and horizontal gene transfer. Wassenaar TM, Fry BN, Van der Zeijst BAM. (1995) Microbiology 141: 95-101.
  • Pathogenitätsfaktoren von enteritischen Salmonellen. Loos M and Wassenaar TM  (1994) Immunität und Infektion, 22: 14-19.
  • Differential flagellin expression in a flaAflaB+ mutant of Campylobacter jejuni. Wassenaar TM, Bleumink-Pluijm NMC, Newell DG, Nuijten PJM, Van der Zeijst BAM. (1994) Infect Immun. 62: 3901-3906.
  • Isotype, specificity, and kinetics of systemic and mucosal antibodies to Campylobacter jejuni antigens, including flagellin, during experimental oral infections of chickens. Cawthraw SA, Ayling R, Nuijten P, Wassenaar T, Newell DG. (1994) Avian Dis. 38: 341-349.
  • Colonization of chicks by motility mutants of Campylobacter jejuni demonstrates the importance of flagellin A expression. Wassenaar TM, Van der Zeijst BAM, Ayling R, Newell DG. (1993) J Gen Microbiol. 139: 1171-1175.
  • Genetic manipulation of Campylobacter: evaluation of natural transformation and electro-transformation. Wassenaar TM, Fry BN, Van der Zeijst BAM. (1993) Gene 132, 131-135
  • Inactivation of Campylobacter jejuni flagellin genes by homologous recombination demonstrates that flaA but not flaB is required for invasion. Wassenaar TM, Bleumink-Pluym NMC, Van der Zeijst BAM. (1991) EMBO J. 10: 2055-2061.
  • Variations in Campylobacter jejuni flagellin, and flagellin genes, during in vivo and in vitro passage. King V, Wassenaar T, Van der Zeijst BAM, Newell DG (1991) Microb Ecol Health Dis. 4: 135-140.
  • The extended promoter of the gene encoding the ribosomal protein S33 in yeast consists of multiple binding elements. Herruer MH, Mager WH, Doorenbosch TM, Wessels PLM, Wassenaar TM, Planta RJ (1989) Nucl Acids Res. 17: 7427-7439.
  • Cytidylate cyclase activity: identification of cytidine 3',5'-cyclic monophosphate and four novel cytidine cyclic phosphates as biosynthetic products from cytidine triphosphate. Newton RP, Hakeem NA, Salvage BJ, Wassenaar G,  Kingston EE. (1988) Rapid Commun Mass Spectrom. 2:118-126.
  • Transcriptional control of yeast ribosomal protein synthesis during carbon-source upshift. Herruer MH, Mager WH, Woudt LP, Nieuwint RTM, Wassenaar GM, Groenevelt P, Planta RJ  (1987) Nucl Acids Res. 15: 10133-10144.
  • Structural and putative regulatory sequences of the gene encoding ribosomal protein L25 in Candida utilis. Woudt LP, Mager WH, Beek JG, Wassenaar GM , Planta RJ (1987) Curr Genet. 12: 193-198.
  • Analysis of upstream activation sites of yeast ribosomal protein genes. Woudt LP, Mager WH, Nieuwint RTM, Wassenaar GM, Van der Kuyl AC, Murre JM, Hoekman MFM, Brockhoff PGM, Planta RJ (1987) Nucl. Acids Res. 15: 6037-6048.
  • Specific binding of TUF factor to upstream activation sites of yeast ribosomal protein genes. Vignais ML, Woudt LP, Wassenaar GM, Mager WH, Sentenac A, Planta RJ (1987) EMBO J. 6: 1451-1457.
  • Mitochondrially encoded resistance to Paromomycine in Saccharomyces cerevisiae: reinvestigation of a controversy. Tabak HF, Van der Laan JC, Landegent JE, Evers RF, Wassenaar GM  (1982) Plasmids 8: 261-275